Does tocilizumab combined with 30 mg/(kg·day) methylprednisolone improve neurological outcomes compared to 20 mg/(kg·day) in children with acute necrotizing encephalopathy?
A higher initial dose of methylprednisolone (30 mg/kg/day) combined with tocilizumab may offer neuroprotective advantages over a 20 mg/kg/day dose in pediatric acute necrotizing encephalopathy.
In pediatric ANE, tocilizumab combined with 30 mg/(kg·day) MP was associated with improved neurological outcomes compared with 20 mg/(kg·day), with comparable mortality and safety profiles. These findings suggest that a higher initial MP dose may offer neuroprotective advantages, warranting further validation in prospective, multicenter studies.
Li et al. (Tue,) studied this question.