The association of GNAS defects with pro-inflammatory adipokine levels in pseudohypoparathyroidism type 1

Key Points

• GNAS defects are associated with elevated pro-inflammatory adipokines in patients with pseudohypoparathyroidism type 1.
• Levels of adipokines such as leptin and resistin were significantly higher in affected individuals.
• Observational analysis across multiple centers showed consistent biomarkers correlating with GNAS mutations.
• The findings highlight potential inflammatory processes that may contribute to the disease pathology.