March 3, 2026Open Access

Targeting Oxidative Stress and Apoptosis via PI3K/Akt/Nrf2 Pathway: The Therapeutic Role of Bletilla striata Polysaccharide in Diabetic Wound Repair

Key Points

Bletilla striata polysaccharide significantly promotes healing in diabetic wounds, demonstrating its therapeutic potential.
The study highlights a pivotal role of the PI3K/Akt/Nrf2 pathway in enhancing wound repair mechanisms in diabetic conditions.
Analysis integrated oxidative stress management and anti-apoptotic effects to establish treatment protocols.
This study suggests that natural polysaccharides like Bletilla striata may provide valuable therapeutic options in managing diabetes-related complications.

Abstract

Our research emphasizes that BSP serves as a potential therapeutic resolution targeting diabetic wounds for its excellent OS-relieving and antiapoptosis properties. Our findings reveal the value of natural polysaccharides in the treatment of the complications of diabetes and indicate that BSP promotes the healing of diabetic wounds via the PI3K/Akt/Nrf2 signaling pathway.

Targeting Oxidative Stress and Apoptosis via PI3K/Akt/Nrf2 Pathway: The Therapeutic Role of Bletilla striata Polysaccharide in Diabetic Wound Repair

Key Points

Abstract

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