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Peripheral inflammation mediates the relationship between early life stress and alcohol use | Synapse
March 3, 2026
Open Access
Peripheral inflammation mediates the relationship between early life stress and alcohol use
KM
Kaitlin R. McManus
University of California, Los Angeles
CE
Craig K. Enders
University of California, Los Angeles
DK
Dylan Kirsch
University of California, Los Angeles
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Key Points
Peripheral inflammation is a key mediator in the relationship between early life stress and alcohol use.
Findings suggest that individuals facing early life stress have heightened peripheral inflammation levels, influencing alcohol consumption behaviors.
The approach used in this analysis involved examining biomarkers of inflammation in relation to reported alcohol use.
These findings highlight the importance of targeting inflammation to prevent alcohol use related to early life stress.
Abstract
NCT03594435, registered July 11, 2018.
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McManus et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75bbac6e9836116a23957
https://doi.org/https://doi.org/10.1007/s00213-026-07009-8
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