March 3, 2026Open Access

Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway

Key Points

Tanshinone IIA mitigates inflammation, leading to protective effects against acute kidney injury.
The modulation of the DUSP10/JNK/P38/NLRP3 pathway is crucial for its beneficial effects.
The analysis suggests that tanshinone IIA may serve as a therapeutic strategy for septicemia-induced acute kidney injury.
Further investigation is warranted to confirm its efficacy and safety in clinical settings.

Abstract

Tanshinone IIA exerts a protective effect against SA-AKI by mitigating inflammation and apoptosis. Mechanistically, these effects appear to be mediated through DUSP10 and modulation of the JNK/P38/NLRP3 pathway. These findings suggest that tanshinone IIA might be a potential therapeutic strategy for SA-AKI.

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Cite This Study

Dan Wen (Thu,) studied this question.

synapsesocial.com/papers/69a75be4c6e9836116a240e7 https://doi.org/https://doi.org/10.62347/vjei5652

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