Microbiota-derived butyric acid activates GPR41/43/109A signaling to restore intestinal barrier integrity and mediate the anti-colitic effect of Sophora alopecuroides extract

Key Points

• Butyric acid activation improved intestinal barrier integrity, showcasing its protective role against colitis.
• The study highlights significant signaling through GPR41, GPR43, and GPR109A influenced by butyric acid.
• Analyses indicate that Sophora alopecuroides extract may provide anti-colitic effects enhanced by microbiota-derived metabolites.
• Restoration of the intestinal barrier suggests promising therapeutic avenues for treating colitis-related disorders.