CCL25/CCR9-induced M2 macrophage polarization promotes lung cancer progression via TGF-β1-mediated activation of the JAK/STAT-PIM2 signaling pathway | Synapse
March 3, 2026
CCL25/CCR9-induced M2 macrophage polarization promotes lung cancer progression via TGF-β1-mediated activation of the JAK/STAT-PIM2 signaling pathway
Key Points
M2 macrophage polarization significantly promotes lung cancer progression, indicating a crucial role in tumor dynamics.
Activation of the JAK/STAT-PIM2 signaling pathway enhances this promotion, potentially serving as a therapeutic target.
CCL25 and CCR9 are key players in this process, altering the tumor microenvironment to favor cancer growth.
Insights call for further exploration of targeted therapies that inhibit this signaling pathway to slow lung cancer progression.