March 3, 2026Open Access

Case Report: Three-fraction lattice radiotherapy followed by VMAT concurrent chemoradiotherapy in locally advanced non–small cell lung cancer

Key Points

Short-term efficacy observed in locally advanced lung cancer using combined lattice radiotherapy and VMAT.
The approach maintained organ at risk doses within safe limits, which is crucial for patient health.
Observational analysis highlights the role of adaptive replanning during treatment for improved outcomes.
This strategy may offer a tailored option for patients with complex tumor volumes and challenging cases.

Abstract

This case suggests that, in unresectable stage III pulmonary squamous cell carcinoma, a combined strategy of limited-fraction LRT plus VMAT with concurrent chemotherapy, together with on-treatment adaptive replanning, can achieve favorable short-term efficacy and acceptable toxicity while maintaining OAR doses within constraints. This approach provides a practical reference for individualized radiotherapy with complex target volumes.

Case Report: Three-fraction lattice radiotherapy followed by VMAT concurrent chemoradiotherapy in locally advanced non–small cell lung cancer

Key Points

Abstract

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