Leptin-dependent fat accumulation triggers autophagy in metabolic dysfunction-associated steatohepatitis model

Key Points

• Autophagy was significantly prompted by leptin loss in obese mice models, influencing metabolic processes.
• Oleic acid administration in LEP-/- cells enhanced autophagy in both hepatocyte-like cells and human HSCs.
• Utilization of obese mice provided insights into the role of leptin in metabolic dysfunction and autophagy.
• Findings imply potential therapeutic targets involving autophagy modulation in metabolic diseases.