Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

Key Points

• Neuroinflammation and oxidative stress responses are elevated in depression models, impacting their progression.
• Key evidence shows that peroxiredoxins Prdx1, Prdx2, Prdx4, and Prdx5 were significantly increased in these models.
• Analysis focuses on the role of lipopolysaccharide in triggering neuroinflammation in depression models.
• Findings may enable new therapeutic strategies targeting oxidative stress and inflammation in depression.