Comprehensive pharmacokinetic and tissue distribution study of α,ω-dipropionic acid polyethylene glycol (PA-PEG₁₂-PA) in rats using a validated UPLC-MS/MS method

Key Points

• Identifying prominent tissue distribution patterns, PA-PEG12-PA demonstrated significant presence in the liver and kidneys.
• The peak plasma concentration of PA-PEG12-PA was recorded at 1 hour post-administration, providing essential pharmacokinetic insights.
• Analysis using a validated UPLC-MS/MS method revealed detailed pharmacokinetics of PA-PEG12-PA at varying doses across rat models.
• Highlighting potential clinical applications, this study supports future research for drug delivery systems using polyethylene glycol derivatives.