Voltage-gated sodium channels (VGSCs/Navs) are essential targets for the treatment of numerous neurological, muscular, and cardiac disorders. Despite the increasing clinical interest in subtype-selective modulators, current public databases provide fragmented and inconsistent information on VGSC-related compounds and targets, particularly lacking coverage on peptides. To address this limitation, we developed NavDB, a specialized and open-access database focusing on VGSC modulators and targets. NavDB integrates 8023 curated data records covering 5168 compounds, including small molecules, toxins, drugs, and peptides, along with comprehensive annotations on biological activity, druggability, and structural feature. NavDB also features advanced functions such as text-based and structure-based search, peptide similarity matching, and AI-powered property prediction. Moreover, the database offers high-quality 3D visualizations of targets and peptides, with disulfide bond and signal peptide annotations. All data are freely downloadable to support both experimental and computational drug discovery. NavDB is publicly available at: http://cadd.zju.edu.cn/navdb/.
Wang et al. (Wed,) studied this question.