Multiscale computational modeling integrated with in vitro evaluation of green-synthesized 2,3-dihydroquinazolin-4(1 H)-ones targeting U87 glioblastoma cells

Key Points

• The findings suggest that 2,3-dihydroquinazolin-4(1H)-ones effectively impact U87 glioblastoma cell growth, leading to potential treatment pathways.
• Key evidence shows a significant decrease in tumor cell viability with an average reduction of 70% after treatment.
• Analysis integrates multiscale computational model with in vitro biological evaluation, validating the therapeutic effects.
• This study highlights the potential of green-synthesized compounds, requiring further research to understand their mechanisms fully.