March 3, 2026Open Access

RV-PA Uncoupling Is Associated With 1-Year Mortality in ST-Segment Elevation Myocardial Infarction

Key Points

1-year all-cause mortality is significantly predicted by RV-PA uncoupling in STEMI patients, indicating critical implications for risk assessment.
The TAPSE/sPAP ratio threshold of 0.405 mm/mm Hg serves as a key marker for identifying patients at higher mortality risk.

Structured PICO

Is RV-PA uncoupling associated with 1-year mortality in STEMI patients?

Population

STEMI patients

Intervention

RV-PA uncoupling (TAPSE/sPAP ratio < 0.405 mm/mm Hg)

Outcome

1-year all-cause mortalityhard clinical

RV-PA uncoupling (TAPSE/sPAP ratio < 0.405 mm/mm Hg) serves as an independent predictor of 1-year all-cause mortality in STEMI patients, aiding in early risk stratification.

Abstract

This study highlights the importance of hemodynamic equilibrium between the RV and pulmonary circulation in STEMI patients. RV-PA uncoupling (TAPSE/sPAP ratio < 0.405 mm/mm Hg) is an independent predictor of 1-year all-cause mortality in these patients, aiding in early risk stratification.

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Cite This Study

Krefting et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75d07c6e9836116a26705 https://doi.org/https://doi.org/10.1016/j.jcin.2025.12.003

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