SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion

Key Points

• Nucleocapsid protein interacts with soluble complement regulatory proteins, enhancing virion stability.
• This complex formation may help SARS-CoV-2 evade host immune responses, impacting infection outcomes.
• Assessment of protein interactions indicates significant binding affinity, contributing to virion integrity.
• Understanding these interactions emphasizes the need for targeted therapies against COVID-19.