Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution

Key Points

• Clonal evolution occurs predominantly within single cells, indicating distinct genetic trajectories.
• Significant findings include the presence of extrachromosomal DNA influencing cellular behavior.
• Observational analysis across multiple genetic contexts demonstrates adaptive selection of specific DNA structures.
• Findings emphasize the intricate relationship between genetic material and cellular evolution, suggesting broader implications for cancer research.