Integrated multi-platform metabolomics reveals fatty acid-mediated inflammatory signatures in pretibial myxedema

Key Points

• Accumulation of fatty acids is linked to fibroblast-mediated inflammation and fibrosis in the dermis, presenting a novel insight into skin disorders.
• Fatty acid-mediated inflammation reveals critical signatures affecting disease progression, highlighting potential therapeutic targets.
• Assessment of metabolic pathways shows that fatty acids play a significant role in the pathogenesis of pretibial myxedema, impacting treatment strategies.
• These findings may enable new approaches for managing inflammatory conditions related to metabolic dysfunction in skin diseases.