Metal–atovaquone complexes with antiplasmodial activity: chemical reactivity and structure–activity relationships | Synapse
March 3, 2026
Metal–atovaquone complexes with antiplasmodial activity: chemical reactivity and structure–activity relationships
Key Points
Antimalarial activity was potent in metal complexes with atovaquone, indicating their therapeutic potential.
Complexes featuring silver, zinc, and copper exhibited significant selectivity against malaria parasites.
Observation leveraged chemical reactivity to explore structure-activity relationships in the complexes.
The findings highlight the need for further studies on metal complexes for developing effective antimalarial treatments.
Abstract
Five new promising antimalarial metallodrugs (M (Ag, Zn, and Cu)–atovaquone (ATV)) were obtained. These demonstrate potent antimalarial activity, selectivity, and tunable action phenotypes.