Integrating lymphovascular and perineural invasion into TNM staging: a novel ITNM system for enhanced prognostic stratification in colorectal cancer

Key Points

• The ITNM system enhances prognostic accuracy by integrating lymphovascular invasion and perineural invasion into the existing TNM staging.
• Key evidence shows this novel system allows for better risk-adapted therapeutic decision-making, potentially altering treatment pathways for colorectal cancer.
• Analysis of the ITNM system illustrates its effectiveness in improving prognostic assessments in patients with colorectal cancer.
• This significant development calls for broader implementation in clinical practice to refine cancer staging and improve patient outcomes.