Our findings indicate that NAPQI adduct generation is closely related to acetaminophen HSRs, supporting a mechanistic link between impaired NAPQI detoxification and acetaminophen HSR. Genetic variability in detoxifying enzymes, particularly GSTM1, may modulate individual susceptibility. These findings warrant further investigation into NAPQI adducts as predictive biomarkers for acetaminophen hypersensitivity.
Gomez-Tabales et al. (Wed,) studied this question.