Common and distinct patterns of aberrant amygdala functional connectivity in major depressive disorder and bipolar disorder: A voxel-wise comparative meta-analysis

Key Points

• Aberrant amygdala functional connectivity differentiates major depressive disorder and bipolar disorder, revealing unique patterns.
• The comparative meta-analysis included studies that identified specific connectivity disruptions in both disorders.
• Observational analysis across multiple datasets shows distinctive connectivity alterations in the amygdala for each mood disorder.
• Understanding these neurobiological differences may enable better diagnosis and treatment strategies for mood disorders.