Risk Factors for Falls in Older Depressed Adults Treated with Bupropion: An Analysis of the OPTIMUM Randomized Clinical Trial

Key Points

• Falls were significantly associated with increased depression severity, impacting treatment outcomes.
• A 25% increase in fall risk was observed among those treated with bupropion compared to other treatments.
• Analysis of the OPTIMUM randomized clinical trial data revealed key risk factors for falls among participants.
• Identifying these risks may improve safety protocols for older adults undergoing treatment for depression.