March 3, 2026Open Access

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Key Points

JAML deficiency may lead to disrupted cGAS-STING pathway activation, impacting cancer progression.
Clinically, JAML expression could serve as an important biomarker for predicting treatment response in patients.
Assessment of JAML's role was performed with a focus on immune microenvironment changes during cancer progression.
These findings support the potential for developing tailored immunotherapy strategies in endometrial cancer.

Abstract

These findings suggest that JAML deficiency may suppress cyclic GMP-AMP synthase (cGAS)-STING pathway activation, potentially contributing to M1/M2 macrophage polarization imbalance and facilitating EC progression. Clinically, JAML expression shows promise as a potential biomarker for prognostic stratification and treatment response prediction (chemotherapy/immunotherapy), providing insights for developing precision immunochemotherapy strategies in EC.

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Key Points

Abstract

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