Circulating Tumor DNA as a Biomarker for Recurrence After Curative Resection of Colorectal Cancer Liver Metastases: A Systematic Review and Meta-Analysis

Key Points

• Circulating tumor DNA is a promising biomarker for detecting recurrence after colorectal cancer liver metastases resection.
• The analysis revealed a significant association between circulating tumor DNA levels and recurrence risk, with a pooled hazard ratio of 2.5.
• Systematic review and meta-analysis of existing studies address the utility of circulating tumor DNA in colorectal cancer contexts.
• This study emphasizes the need for further validation in diverse populations to solidify its clinical application.