March 3, 2026Open Access

The challenge of staying up-to-date in critical care

Key Points

Non-implementation of new evidence continues to pose challenges in critical care practices, causing potential harm.
The CHEST and 6S trials revealed significant risks associated with hydroxyethyl starch solutions, yet their use persisted.
Mortality rates decreased by ~50% with prone-position ventilation, as seen in the PROSEVA trial, highlighting effective interventions.
Support for evidence-based practices in critical care is crucial; further actions are needed to ensure timely updates.

Abstract

Non-implementation of new evidence is a longstanding issue in medicine. In critical care, the CHEST(1) and 6S(2) trials identified clear harm with the use of hydroxyethyl starch solutions. Yet, they continued to be widely used until regulatory approval was removed(3) or modified.(4) The PROSEVA trial(5) identified a ~50% absolute mortality reduction from prone-position ventilation in …

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Cite This Study

Rob Mac Sweeney (Thu,) studied this question.

synapsesocial.com/papers/69a75de6c6e9836116a28310 https://doi.org/https://doi.org/10.62675/2965-2774.20260344

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