Molecular Mechanisms of Shenhong Tongluo Formula Against Myocardial Ischemia-Reperfusion Injury: Insights from RNA Sequencing, Bioinformatics, Reverse Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations Combined with Experimental Studies | Synapse
March 3, 2026
Molecular Mechanisms of Shenhong Tongluo Formula Against Myocardial Ischemia-Reperfusion Injury: Insights from RNA Sequencing, Bioinformatics, Reverse Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations Combined with Experimental Studies
Key Points
Shenhong Tongluo Formula significantly reduces myocardial ischemia-reperfusion injury outcomes, showing potential for heart protection.
RNA sequencing and bioinformatics tools identified key pathways affected by the formula, particularly those related to inflammation.
The approach includes reverse network pharmacology and molecular docking, validating interactions at the molecular level.
These findings may enable targeted therapies for myocardial ischemia, although experimental studies are required for further validation.