The atypical kinase right open reading frame kinase 1 suppresses glioma cell growth through mammalian target of rapamycin inhibition and apoptotic signaling activation

Key Points

• RIOK1 expression is significantly lower in glioma tissues compared to non-tumor brain tissues.
• Lower RIOK1 levels correlate with increased cell survival and proliferation in IDH wild-type gliomas.
• Analysis of RIOK1 highlights its role in inhibiting the mTOR pathway, which is crucial for cell growth.
• The findings suggest that targeting RIOK1 might offer new strategies for glioma treatment, particularly in specific glioma subtypes.