Clinical utility of OGN in pan-cancer: diagnostic biomarker and immune microenvironment regulator

Key Points

• Highlights the role of OGN as a multifunctional biomarker in cancer signaling, particularly for immune and angiogenic pathways.
• OGN dysregulation may serve as a diagnostic and prognostic marker across various cancer types, enhancing patient management.
• The observational analysis links extracellular matrix remodeling with immune evasion, underscoring OGN's significance in tumor biology.
• This work suggests that targeting OGN could improve cancer therapies, though further validation in clinical settings is necessary.