snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses

Key Points

• Distinct glial responses categorize multiple sclerosis patients based on their white matter analysis, indicating varied disease mechanisms.
• The analysis identified two major clusters in the response profiles, highlighting potential therapeutic targets for MS.
• Assessment using single-nucleus RNA sequencing, which provides high-resolution insights into cellular responses in brain tissue.
• Supports the need for further exploration of glial responses as biomarkers for personalized treatment strategies.