Coordinating metabolic reprogramming and exosome secretion: A dual role for SIRT1/HIF-1α under hypoxia in golden pompano

Key Points

• Metabolic reprogramming occurs in golden pompano, driven by sirt1 and hif-1α under hypoxia conditions, enhancing survival.
• Exosome secretion is also regulated by these pathways, indicating a complex interplay in stress response.
• Assessment of molecular pathways suggests that both sirt1 and hif-1α are crucial for adapting to low oxygen environments.
• Potential implications include strategies for improving fish resilience to hypoxic conditions, aiding aquaculture practices.