miR-381-3p suppresses pterygium progression by regulating HACE1/TRIP12-mediated ubiquitin-degradation of MCPIP1

Key Points

• miR-381-3p significantly suppresses MCPIP1 levels, impacting pterygium development.
• The study shows that the modulation of ubiquitin-degradation pathways is crucial via HACE1 and TRIP12 interactions.
• Analysis utilized various cellular models to elucidate the regulatory mechanisms influencing pterygium progression.
• Findings highlight potential therapeutic strategies targeting miR-381-3p for pterygium management.