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Rituximab in Guillain-Barré syndrome (RUGBY) trial: A single center, double-blind, randomized phase 3 trial | Synapse
March 3, 2026
Rituximab in Guillain-Barré syndrome (RUGBY) trial: A single center, double-blind, randomized phase 3 trial
AA
Ayush Agarwal
DG
Divyani Garg
All India Institute of Medical Sciences Bhopal
VV
VY Vishnu
All India Institute of Medical Sciences Raipur
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Key Points
Rituximab shows significant efficacy in treating Guillain-Barré syndrome, improving patient outcomes.
The trial's primary endpoint was reached, indicating favorable results for those receiving rituximab treatment.
This double-blind, randomized phase 3 trial analyzed participants with Guillain-Barré syndrome over a defined period.
Findings may highlight a new therapeutic option for this serious autoimmune disorder.
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Agarwal et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75e98c6e9836116a295a5
https://doi.org/https://doi.org/10.1016/j.jns.2025.124367