Synthesis and integrative multimodal evaluation of cholic acid-based hydrazone conjugates: in vitro, in silico, and in vivo studies

Key Points

• Hydrazone conjugates exhibit notable biological activity, influencing multiple cellular pathways effectively.
• Key metrics demonstrate significant results in 3 multimodal evaluation methods, supporting versatile applications.
• Analysis incorporated in vitro assays, in silico modeling, and in vivo testing to comprehensively evaluate performance.
• Findings highlight the need for broader studies to explore clinical applications and safety profiles.