March 3, 2026Open Access

Targeting the mycobiome in sarcoidosis

Key Points

Diverse fungal communities exist in sarcoidosis patients' blood and respiratory specimens, indicating a potential role in disease.
Findings suggest that fungi may act as antigenic drivers in the immune response related to sarcoidosis.
Integration of epidemiologic and immunologic evidence highlights the need to further investigate fungal-host interactions.
Future functional studies could clarify the immunomodulatory implications of these fungal communities in sarcoidosis.

Abstract

This study provides evidence of diverse fungal communities in sarcoidosis patients' blood and respiratory specimens, with potential immunomodulatory implications. Our findings integrate with existing epidemiologic and immunologic evidence highlighting fungi as credible antigenic drivers in sarcoidosis and suggest directions for future functional studies exploring fungal-host interactions in disease pathogenesis.

Targeting the mycobiome in sarcoidosis

Key Points

Abstract

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