This study is the first patient-level meta-analysis of prospectively collected clinical trial data to evaluate sex as a modifier of prognostic factors for asthma attacks. The overall annualised asthma attack rate was higher in women than men. Prior attack history had stronger prognostic value for future attacks in men, while other clinical risk factors and type-2 biomarkers (blood eosinophils and FeNO) showed no major sex differences. These findings highlight that women without prior attacks may still face increased risk and have important implications for clinical research and practice.
Riemann et al. (Thu,) studied this question.