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March 3, 2026
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes
SG
Simon Grassmann
ES
Endi K. Santosa
Memorial Sloan Kettering Cancer Center
HK
Hyunu Kim
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Key Points
Adaptive programming enhances cytotoxic lymphocyte functions, improving immune responses against infections.
Key findings showed that epigenetic adaptations drive modifications in cellular behavior as lymphocytes encounter signals.
Analysis utilized methods focusing on molecular pathways influencing lymphocyte development and function.
This work supports advancing treatments targeting immune responses, though further validation in clinical settings is required.
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Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes | Synapse
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Grassmann et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f41c6e9836116a2a7f1
https://doi.org/https://doi.org/10.1016/j.immuni.2026.01.004