Effect of Long Noncoding RNA PVT1 on Epithelial Barrier in Chronic Rhinosinusitis with Nasal Polyps

Key Points

• Epithelial barrier function is significantly affected by long noncoding RNA PVT1 in chronic rhinosinusitis with nasal polyps.
• An increase in PVT1 expression correlates with altered gene expression and diminished barrier integrity in epithelial cells.
• Observational analysis investigated the relationship between long noncoding RNA PVT1 and epithelial barrier disruptions.
• Findings indicate a potential role for targeting long noncoding RNA PVT1 in treating chronic rhinosinusitis with nasal polyps.