March 3, 2026Open Access

H4K20me3 and CTCF act reciprocally at TAD boundaries to regulate cell state transitions

Key Points

Cells shift between proliferative and quiescent states based on H4K20me3 and CTCF levels.
Increased H4K20me3 links to larger mice, suggesting hyperproliferation under certain conditions.
Analysis indicates competition between H4K20me3 and CTCF is critical at chromatin boundaries.
The findings may highlight potential targets for regulating cell growth and differentiation.

Abstract

H4K20me3, a mark associated with heterochromatin, and CTCF compete for chromatin boundary elementsCTCF and H4K20me3 play opposing roles, with increased CTCF in proliferating cells and elevated H4K20me3 in quiescent cellsModulating H4K20me3 or CTCF reversibly shifts cells between proliferative and quiescent stateMice with reduced H4K20me3 are larger, consistent with hyperproliferation.

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Cite This Study

Atai et al. (Fri,) studied this question.

synapsesocial.com/papers/69a75f5fc6e9836116a2ab5c https://doi.org/https://doi.org/10.64898/2026.01.29.702647

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