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C5-arylidene rhodanine scaffolds from L-phenylalanine and core structures: Synthesis and anticancer evaluation | Synapse
March 3, 2026
C5-arylidene rhodanine scaffolds from L-phenylalanine and core structures: Synthesis and anticancer evaluation
EK
Erbay Kalay
Kafkas University
ŞA
Şakir Akgün
Kafkas University
BÇ
Batuhan Çakmakçı
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Key Points
C5-arylidene rhodanine scaffolds show significant anticancer activity, with tests indicating efficacy against various cancer cell lines.
The synthesis involved combining L-phenylalanine with different core structures to create novel compounds known for their therapeutic potential.
Observational analysis of synthesized compounds revealed promising results which suggest further exploration in cancer therapy is warranted.
Implications support the need for more in-depth studies to confirm the effects of these scaffolds, establishing a foundation for future research.
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Kalay et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f84c6e9836116a2af01
https://doi.org/https://doi.org/10.1016/j.molstruc.2026.145520