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March 3, 2026
Comparable High-Grade Toxicity with Axi-Cel Plus Dexamethasone Prophylaxis Versus Liso-Cel: A Real-World Analysis
NB
Nicholas Barnaba
Temple University Hospital
CD
Christina C Darwish
RT
Riya Tandra
Temple University Hospital
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Key Points
Axi-cel with dexamethasone shows comparable high-grade toxicity to Liso-cel in patients treated with CAR T therapy.
Patients receiving Axi-cel experienced 72% high-grade toxicity incidence, matching Liso-cel outcomes closely.
Analysis based on real-world data assessing treatments reveals significant implications for patient management.
Findings suggest the need for careful monitoring and potential adjustments in toxicity management strategies.
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Comparable High-Grade Toxicity with Axi-Cel Plus Dexamethasone Prophylaxis Versus Liso-Cel: A Real-World Analysis | Synapse
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Barnaba et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7602cc6e9836116a2cab0
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.543