Astragalus polysaccharide enhances the antitumor efficacy of sunitinib in renal cell carcinoma by targeting the ZEB1-SCD1-Wnt/β-Catenin signaling pathway | Synapse
March 3, 2026
Astragalus polysaccharide enhances the antitumor efficacy of sunitinib in renal cell carcinoma by targeting the ZEB1-SCD1-Wnt/β-Catenin signaling pathway
Key Points
Astragalus polysaccharide significantly increases the antitumor efficacy of sunitinib in renal cell carcinoma.
The study highlights the specific targeting of the ZEB1-SCD1-Wnt/β-catenin signaling pathway as a critical mechanism.
Assessment using cell line models demonstrates profound synergistic effects in tumor growth inhibition with combined treatment.
These findings may suggest a promising therapeutic strategy to enhance cancer treatment outcomes, with further research needed for clinical validation.