March 3, 2026Open Access

Characterization of a conjugative IncFII/IncR plasmid harboring blaKPC-2 in a clinical ST91 Citrobacter freundii isolate

Key Points

Plasmid lineages drive carbapenem resistance dissemination in bacteria, emphasizing public health concerns.
Characterization involves analysis of the IncFII/IncR plasmid that carries the blaKPC-2 resistance gene.
Assessment focused on a clinical isolate of Citrobacter freundii to understand resistance transfer mechanisms.
Highlights the importance of plasmid surveillance to monitor antibiotic resistance spread in clinical settings.

Abstract

To our knowledge, this is the first characterization of an IncFII(pBK30683)/IncR plasmid carrying blaKPC-2 in a clinical C. freundii ST91 isolate. The findings highlight plasmid lineages as drivers of carbapenem resistance dissemination and underscore the need for plasmid-focused genomic surveillance, particularly for monitoring transferable resistance vehicles across clinically relevant hosts.

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Authors

Xiao Liu

Harbin Engineering University

Zhen Liu

Chinese Academy of Sciences

Zhiwen Sun

National Institute for Communicable Disease Control and Prevention

Journals

BMC Microbiology

Actions

Institutions

Chinese Academy of Sciences

Institute of Microbiology

National Institute for Communicable Disease Control and Prevention

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Liu et al. (Wed,) studied this question.

synapsesocial.com/papers/69a7604cc6e9836116a2ce8a — DOI: https://doi.org/10.1186/s12866-026-04795-1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Major Variation in MICs of Tigecycline in Gram-Negative Bacilli as a Function of Testing Method· 2014 · 84 citations
Co-selection of antibiotic and metal resistance· 2006 · 1,854 citations
FastME 2.0: A Comprehensive, Accurate, and Fast Distance-Based Phylogeny Inference Program: Table 1.· 2015 · 1,790 citations
Multiplex PCR for detection of acquired carbapenemase genes· 2011 · 1,994 citations
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era· 2020 · 16,459 citations

Characterization of a conjugative IncFII/IncR plasmid harboring blaKPC-2 in a clinical ST91 Citrobacter freundii isolate

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

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Also consider