A systematic review and meta-analysis of the relationship between neuroinflammation and blood-brain barrier based on in vitro models

Key Points

• Neuroinflammation negatively impacts the blood-brain barrier integrity, suggesting a significant relationship.
• The analysis shows a strong correlation, with cytokine levels identified as key mediators in the barrier disruption.
• Systematic review and meta-analysis based on multiple in vitro models demonstrate clear trends in responses to inflammation.
• Findings may support future therapeutic interventions targeting neuroinflammation for neuroprotective strategies.