Eosinophilic esophagitis (EoE) is a chronic, antigen-mediated inflammatory condition of the esophagus, characterized by signs of esophageal dysfunction and characteristic endoscopic and histological features. Currently, EoE has developed from a rare disease entity to a prevalent condition with a rising incidence and prevalence in children. Over the past few decades, a deeper understanding of the underlying pathophysiologic mechanisms of EoE has led to better diagnostic and therapeutic strategies. Pediatric patients with EoE face a diagnostic dilemma due to a wide spectrum in symptomatology as well as limited pharmacological armamentarium. Emerging literature is showing promise, especially with dupilumab, a newer biologic with disease modifying potential. In this review we discussed new diagnostic and treatment strategies and future directions of monitoring EoE in children.
Samanta et al. (Wed,) studied this question.