Ex Vivo Expanded Mcam CAR NK Cells in Combination with Anti-GD2 Antibody Significantly Reduced Tumor Growth in Osteosarcoma Xenograft Model

Key Points

• Tumor growth significantly decreased when using Mcam CAR NK cells combined with anti-GD2 antibody, indicating potential therapeutic benefits.
• A notable reduction in tumor size was observed, with a measurement of 56%, suggesting strong anti-tumor activity.
• Analysis of an osteosarcoma xenograft model was conducted, highlighting the promising interaction between immunotherapy components.
• These findings imply that combining CAR NK cells with specific antibodies may offer a novel approach for treating osteosarcoma.