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March 3, 2026
Open Access
Fibrosis and Myocardial Dysfunction in Hypertrophic Cardiomyopathy
TZ
Thomas Zegkos
Heart Failure & Transplant
TG
Thomas Gossios
Heart Failure & Transplant
DP
Despοina Parcharidou
Leiden University Medical Center
Key Points
Myocardial dysfunction is significantly associated with fibrosis in hypertrophic cardiomyopathy.
Evidence indicates that interventions targeting fibrosis may improve myocardial function in affected individuals.
Analysis of cardiac images and biomarkers was used to assess the pathophysiology of myocardial dysfunction.
Further exploration of treatment strategies could enhance outcomes for hypertrophic cardiomyopathy patients.
Abstract
Figure: see text
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Zegkos et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760c8c6e9836116a2ddc7
https://doi.org/https://doi.org/10.1016/j.jacasi.2025.12.001
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Fibrosis and Myocardial Dysfunction in Hypertrophic Cardiomyopathy | Synapse