De-escalating radiotherapy in pathologic complete response oral cancer after neoadjuvant immunochemotherapy: equal survival, better life, and a biomarker guide

Key Points

• Equal survival observed despite omitting adjuvant radiotherapy after pCR in oral cancer patients.
• Adjuvant radiotherapy was omitted in a patient cohort achieving pathologic complete response after neoadjuvant immunotherapy.
• Assessment used an integrated TP53/B-cell biomarker model for personalizing the treatment approach.
• Highlights the potential for improved patient quality of life while maintaining effective cancer care.