Petiveria alliacea L. methanolic extract inhibits amyloid-β aggregation and enhances cell viability in SH-SY5Y cells: in vitro and in silico evidence

Key Points

• Methanolic extract significantly inhibits amyloid-β aggregation, enhancing cell viability in SH-SY5Y cells.
• Cell viability improved by up to 40% following treatment with the extract, indicating a strong protective effect.
• In vitro experiments were complemented by in silico analysis to understand molecular mechanisms behind the effects.
• The findings suggest potential for therapeutic development targeting amyloid-β related neurodegeneration.