Gomisin A and metformin co-treatment attenuates diabetic nephropathy and cardiovascular dysfunction by modulating the AGE/RAGE pathway in a diabetic rat model

Key Points

• Co-treatment with gomisin a and metformin significantly alleviates diabetic nephropathy symptoms.
• The study found reduced cardiovascular dysfunction indicators in diabetic rats receiving dual therapy.
• Analysis highlights modulation of the age/rage pathway as a key mechanism in this co-treatment approach.
• These findings suggest that combined therapies may improve management of diabetes-related complications.