What does this research mean for the field?

In elderly anticoagulated patients, the addition of antidepressants, chronic kidney disease, and concomitant antiplatelet therapy significantly increase the risk of a 90-day emergency department revisit for gastrointestinal bleeding. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2026Open Access

Risk factors for emergency department revisit among elderly patients with gastrointestinal bleeding secondary to oral anticoagulant therapy

Key Result

In elderly anticoagulated patients, antidepressants significantly increase 90-day ED revisit risk for gastrointestinal bleeding, with chronic kidney disease and antiplatelet therapy also key risk fact

Key Points

Emergency department revisits increase for elderly patients on anticoagulant therapy, particularly with added antidepressants.
Among the observed 90-day period, those with chronic kidney disease faced heightened risks as well.
Utilizing retrospective analysis, key risk factors were identified linked to previous emergency visits for bleeding.
Findings emphasize monitoring patients on anticoagulants, particularly those with mental health treatment or kidney issues.

Structured PICO

Do antidepressants, antiplatelet therapy, or chronic kidney disease increase the risk of ED re-visit for gastrointestinal bleeding within 90 days in elderly patients on oral anticoagulants?

Population

Elderly patients with gastrointestinal bleeding secondary to oral anticoagulant therapy

Intervention

Addition of antidepressants, concomitant antiplatelet therapy, or presence of chronic kidney disease

Outcome

Emergency department re-visit for gastrointestinal bleeding within 90 dayshard clinical

Concomitant use of antidepressants or antiplatelets, as well as chronic kidney disease, are significant risk factors for 90-day ED revisits due to GI bleeding in elderly patients on oral anticoagulants.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

In elderly patients anticoagulated, the addition of antidepressants significantly increases the risk of ED re-visit for gastrointestinal bleeding within 90 days. Chronic kidney disease and concomitant antiplatelet therapy also emerge as key risk factors.